                         SEQUENCE LISTING

<110>  Wyeth
 
<120>   Antibody Against GDF8 and the Uses Thereof

<130>  AM102658

<150>  61/001783
<151>  2007-11-01

<160>  36    

<170>  PatentIn version 3.3

<210>  1
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu 
        35                  40                  45              


Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210>  2
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 
1               5                   10                  15      


Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 
            20                  25                  30          


Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 
        35                  40                  45              


Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 
    50                  55                  60                  


Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 
65                  70                  75                  80  


Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 
                85                  90                  95      


Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 
        115                 120                 125             


Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 
    130                 135                 140                 


Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 
                165                 170                 175     


Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 
            180                 185                 190         


Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 
        195                 200                 205             


Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 
    210                 215                 220                 


Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 
225                 230                 235                 240 


Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 
                245                 250                 255     


Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 
            260                 265                 270         


Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
        275                 280                 285             


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
    290                 295                 300                 


Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 
305                 310                 315                 320 


Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 
                325                 330                 335     


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
            340                 345                 350         


Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 
        355                 360                 365             


Val Asp Arg Cys Gly Cys Ser 
    370                 375 


<210>  3
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  3
gattttggtc ttgactgt                                                   18


<210>  4
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Phe Gly Leu Asp Cys 
1               5       


<210>  5
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  5
tttgaagctt ttggatggga ttggattatc gctcctaaaa gatat                     45


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
1               5                   10                  15  


<210>  7
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  7
tttgtatttt tacaaaaata tcctcatact catctggtac accaa                     45


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln 
1               5                   10                  15  


<210>  9
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  9
tgctctggag agtgtgaatt tgtattt                                         27


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Ser Gly Glu Cys Glu Phe Val Phe 
1               5                   


<210>  11
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  11
tggattatcg ctcctaaaag atataaggcc aattactgct ctggagagtg tgaatttgta     60

tttttacaaa aatat                                                      75


<210>  12
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu 
1               5                   10                  15      


Cys Glu Phe Val Phe Leu Gln Lys Tyr 
            20                  25  


<210>  13
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  13
caggttcagc tccagcagtc tggggctgag ctggcaagac ctggggcttc agtgaagttg     60

tcctgcaagg cttctggcta cacctttact agctactgga tgcagtgggt aaaacagagg    120

cctggacagg gtctggaatg gattggggct atttatcctg gagatggtga tactaggtac    180

actcagaagt tcaagggcaa ggccacattg actgcagata aatcctccag cacagcctac    240

atgcaactca gcagcttggc atctgaggac tctgcggtct attactgtgc aagaatgggt    300

ggttacgacc ggtactactt tgactactgg ggccaaggca ccactctcac agtctcctca    360


<210>  14
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  14

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Gly Tyr Asp Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  339
<212>  DNA
<213>  Mus Musculus

<400>  15
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact     60

atgagctgca agtccagtca gagcctttta aatagtgcca atcaaaagaa ctatttggcc    120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg    180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc    240

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttataacact    300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                           339


<210>  16
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  17
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Gly Tyr Asp Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  113
<212>  PRT
<213>  Homo sapien

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  19
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  19

Ser Tyr Trp Met Gln 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  20

Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  21

Ala Arg Met Gly Gly Tyr Asp Arg Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  22
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  22

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ala Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  23

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Gln His Tyr Asn Thr Pro Leu Thr 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  25

Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Ala Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5                   


<210>  27
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  27

Ala Arg Met Gly Gly Tyr Asp Arg Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  28
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  28

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ala Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  29
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  29

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  30

Gln Gln His Tyr Asn Thr Pro Leu Thr 
1               5                   


<210>  31
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  31
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc     60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact    120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctcctat    180

ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac    240

ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagacaagac    300

tatgctatga actactgggg tcaaggaacc tcagtcaccg tctcctca                 348


<210>  32
<211>  300
<212>  DNA
<213>  Mus Musculus

<400>  32
gacattgaga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc     60

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca    120

ggacaatctc ctaaactact gctttactcg gcatcctacc ggtacactgg agtccctgat    180

cggttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct    240

gaagacctgg cagtttatta ctgtcagcaa cattatagta ctccgtggac gttcggtgga    300


<210>  33
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  33
caggtgcagc tggtgcaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac    180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagacgag    300

aactgggggt tcgacccctg gggccaggga accctggtca ccgtctcgag t             351


<210>  34
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  34
tcctatgagc tgactcagcc accctcagtg tccgtgtctc caggacagac agccaccatt     60

acctgctctg gacatgcact gggggacaaa tttgtttcct ggtatcagca gggatcaggc    120

cagtcccctg tattggtcat ctatgacgat acccagcggc cctcagggat ccctgggcga    180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg    240

gatgaggctg actatttttg tcaggcgtgg gacagcagct tcgtattcgg cggagggacc    300

aaggtcaccg tccta                                                     315


<210>  35
<211>  1543
<212>  DNA
<213>  Homo sapien

<400>  35
gaacatgacg gcgccctggg tggccctcgc cctcctctgg ggatcgctgt gcgccggctc     60

tgggcgtggg gaggctgaga cacgggagtg catctactac aacgccaact gggagctgga    120

gcgcaccaac cagagcggcc tggagcgctg cgaaggcgag caggacaagc ggctgcactg    180

ctacgcctcc tggcgcaaca gctctggcac catcgagctc gtgaagaagg gctgctggct    240

agatgacttc aactgctacg ataggcagga gtgtgtggcc actgaggaga acccccaggt    300

gtacttctgc tgctgtgaag gcaacttctg caacgaacgc ttcactcatt tgccagaggc    360

tgggggcccg gaagtcacgt acgagccacc cccgacagcc cccaccctgc tcacggtgct    420

ggcctactca ctgctgccca tcgggggcct ttccctcatc gtcctgctgg ccttttggat    480

gtaccggcat cgcaagcccc cctacggtca tgtggacatc catgaggacc ctgggcctcc    540

accaccatcc cctctggtgg gcctgaagcc actgcagctg ctggagatca aggctcgggg    600

gcgctttggc tgtgtctgga aggcccagct catgaatgac tttgtagctg tcaagatctt    660

cccactccag gacaagcagt cgtggcagag tgaacgggag atcttcagca cacctggcat    720

gaagcacgag aacctgctac agttcattgc tgccgagaag cgaggctcca acctcgaagt    780

agagctgtgg ctcatcacgg ccttccatga caagggctcc ctcacggatt acctcaaggg    840

gaacatcatc acatggaacg aactgtgtca tgtagcagag acgatgtcac gaggcctctc    900

atacctgcat gaggatgtgc cctggtgccg tggcgagggc cacaagccgt ctattgccca    960

cagggacttt aaaagtaaga atgtattgct gaagagcgac ctcacagccg tgctggctga   1020

ctttggcttg gctgttcgat ttgagccagg gaaacctcca ggggacaccc acggacaggt   1080

aggcacgaga cggtacatgg ctcctgaggt gctcgaggga gccatcaact tccagagaga   1140

tgccttcctg cgcattgaca tgtatgccat ggggttggtg ctgtgggagc ttgtgtctcg   1200

ctgcaaggct gcagacggac ccgtggatga gtacatgctg ccctttgagg aagagattgg   1260

ccagcaccct tcgttggagg agctgcagga ggtggtggtg cacaagaaga tgaggcccac   1320

cattaaagat cactggttga aacacccggg cctggcccag ctttgtgtga ccatcgagga   1380

gtgctgggac catgatgcag aggctcgctt gtccgcgggc tgtgtggagg agcgggtgtc   1440

cctgattcgg aggtcggtca acggcactac ctcggactgt ctcgtttccc tggtgacctc   1500

tgtcaccaat gtggacctgc cccctaaaga gtcaagcatc taa                     1543


<210>  36
<211>  512
<212>  PRT
<213>  Homo sapien

<400>  36

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


